A Graftable Quaternary Ammonium Biocidal Polymer Reduces Biofilm Formation and Ensures Biocompatibility of Medical Devices
نویسندگان
چکیده
A quaternized polyvinylpyridine (Q-PVP) polymer methanolic solution synthesized in a single step is used to covalently graft titanium surfaces. Q-PVP with varying N+/N ratios. 1 cm2 pure plates are polished and activated. Treated samples grafted by spin coating or dip-coating (grafting-to method). Surfaces characterized X-ray photoelectron spectroscopy, polarization modulation reflection absorption IR atomic force microscopy, scanning electron surface charge density calculation. Polymer leaching assessed at 7 days. Biocompatibility on MC3T3 L929 cells (MTT-assay) SEM. In vitro antibacterial activity methicillin-resistant Staphylococcus aureus (MRSA) 24 h (37 °C brain heart infusion) days biofilm model. Polymers exceeding 31.3 ± 0.7% quaternization led bactericidal Bactericidal increased cationic density. Surface biocompatibility inversely correlated. 44.6 1.2% biocompatible. High-density inhibited MRSA formation. promising candidate for modification. Further vivo studies required.
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ژورنال
عنوان ژورنال: Advanced Materials Interfaces
سال: 2021
ISSN: ['2196-7350']
DOI: https://doi.org/10.1002/admi.202001516