A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers
نویسندگان
چکیده
منابع مشابه
A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers
Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive and memory impairment. It is the most common neurological disease that causes dementia. Soluble amyloid-beta oligomers (AβO) in blood or cerebrospinal fluid (CSF) are the pathogenic biomarker correlated with AD. Methods A simple electrochemical biosensor using graphene oxide/gold nanopar...
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Stabilization, Characterization, and Selective Removal of Cystatin C Amyloid Oligomers*
The pathophysiological process in amyloid disorders usually involves the transformation of a functional monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. In hereditary cystatin C amyloid angiopathy, a cyst...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2018
ISSN: 1178-2013
DOI: 10.2147/ijn.s152163