A model of activity-dependent changes in dendritic spine density and spine structure
نویسندگان
چکیده
منابع مشابه
A compartmental model for activity-dependent dendritic spine branching.
Dendritic spines are small, mushroom-like protrusions from the arbor of a neuron in the central nervous system. Interdependent changes in the morphology, biochemistry, and activity of spines have been associated with learning and memory. Moreover, post-mortem cortices from patients with Alzheimer's or Parkinson's disease exhibit biochemical and physical alterations within their dendritic arbors...
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متن کاملImpact of time-dependent changes in spine density and spine shape on the input-output properties of a dendritic branch: a computational study.
Populations of dendritic spines can change in number and shape quite rapidly as a result of synaptic activity. Here, we explore the consequences of such changes on the input-output properties of a dendritic branch. We consider two models: one for activity-dependent spine densities and the other for calcium-mediated spine-stem restructuring. In the activity-dependent density model we find that f...
متن کاملThe impact of time dependent changes in spine density and spine shape on the input - output properties of a dendritic branch : A computational study
Populations of dendritic spines can change in number and shape quite rapidly as a result of synaptic activity. Here, we explore the consequences of such changes on the input-output properties of a dendritic branch. We consider two models: one for activity-dependent spine densities and the other for calcium mediated spine-stem restructuring. In the activity-dependent density model we find that f...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2007
ISSN: 1471-2202
DOI: 10.1186/1471-2202-8-s2-p91