A modular positive feedback-based gene amplifier

A modular positive feedback-based gene amplifier

BACKGROUND Positive feedback is a common mechanism used in the regulation of many gene circuits as it can amplify the response to inducers and also generate binary outputs and hysteresis. In the context of electrical circuit design, positive feedback is often considered in the design of amplifiers. Similar approaches, therefore, may be used for the design of amplifiers in synthetic gene circuit...

A Modular Operational Amplifier Design

This paper proposes a module of a high gain and high swing 2-stage amplifier. It is suitable for building a general operational amplifier in a modular fashion with various optional performances. The proposed module alone offers opened-loop voltage gain up to 124 dB and GBW of 10 MHz without loading conditions. To assemble a 124 dB voltage gain operational amplifier with load driving capacity of...

High gain two-stage amplifier with positive capacitive feedback compensation

A novel topology for a high gain two-stage amplifier is proposed. The proposed circuit is designed in a way that the non-dominant pole is at output of the first stage. A positive capacitive feedback (PCF) around the second stage introduces a left half plane (LHP) zero which cancels the phase shift introduced by the non-dominant pole, considerably. The dominant pole is at the output node which m...

Comparative Analysis of Positive Feedback and Darlington Pair based Operational Amplifier at 32m Technology

A positive feedback-based gene circuit to increase the production of a membrane protein

BACKGROUND Membrane proteins are an important class of proteins, playing a key role in many biological processes, and are a promising target in pharmaceutical development. However, membrane proteins are often difficult to produce in large quantities for the purpose of crystallographic or biochemical analyses. RESULTS In this paper, we demonstrate that synthetic gene circuits designed specific...