A new insight into male genome reprogramming by histone variants and histone code
نویسندگان
چکیده
منابع مشابه
Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis
During male germ cell postmeiotic maturation, dramatic chromatin reorganization occurs, which is driven by completely unknown mechanisms. For the first time, we describe a specific reprogramming of mouse pericentric heterochromatin. Initiated when histones undergo global acetylation in early elongating spermatids, this process leads to the establishment of new DNA packaging structures organizin...
متن کاملStructural and Functional Analysis of Histone Variants Involved in Reprogramming
During mammalian spermatogenesis, chromatin undergoes stagespecific structural reorganization. Th2a and Th2b are major testisspecific histone variants, and our recent studies suggest that they are involved in reprogramming. Here, the crystal structure of nucleosome core particles (NCPs) with mouse Th2a and Th2b variants will be presented. Intriguingly, NCPs consisting of either Th2a, Th2b or bo...
متن کاملOrganizing the genome with H2A histone variants.
Chromatin acts as an organizer and indexer of genomic DNA and is a highly dynamic and regulated structure with properties directly related to its constituent parts. Histone variants are abundant components of chromatin that replace canonical histones in a subset of nucleosomes, thereby altering nucleosomal characteristics. The present review focuses on the H2A variant histones, summarizing curr...
متن کاملHistone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency.
There are seven linker histone variants in human somatic cells (H1.0 to H1.5 and H1X), and their prevalence varies as a function of cell type and differentiation stage, suggesting that the different variants may have distinct roles. We have revisited this notion by using new methodologies to study pluripotency and differentiation, including the in vitro differentiation of human embryonic stem (...
متن کاملEpigenetic regulation by histone methylation and histone variants.
Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational modifications are now beginning to be elucidated....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2008
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.7.22.6975