A novel fuzzy logic based reverse engineering of gene regulatory network
نویسندگان
چکیده
منابع مشابه
Efficient Reverse-Engineering of a Developmental Gene Regulatory Network
Understanding the complex regulatory networks underlying development and evolution of multi-cellular organisms is a major problem in biology. Computational models can be used as tools to extract the regulatory structure and dynamics of such networks from gene expression data. This approach is called reverse engineering. It has been successfully applied to many gene networks in various biologica...
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Reverse engineering of gene regulatory networks has been an intensively studied topic in bioinformatics since it constitutes an intermediate step from explorative to causative gene expression analysis. Many methods have been proposed through recent years leading to a wide range of mathematical approaches. In practice, different mathematical approaches will generate different resulting network s...
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BACKGROUND The recent DREAM4 blind assessment provided a particularly realistic and challenging setting for network reverse engineering methods. The in silico part of DREAM4 solicited the inference of cycle-rich gene regulatory networks from heterogeneous, noisy expression data including time courses as well as knockout, knockdown and multifactorial perturbations. METHODOLOGY AND PRINCIPAL FI...
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ژورنال
عنوان ژورنال: Future Computing and Informatics Journal
سال: 2017
ISSN: 2314-7288
DOI: 10.1016/j.fcij.2017.07.002