A Polymorphic Residue That Attenuates Interferon Lambda 4 Activity in Hominid Lineages

Antiviral activity of lambda interferon in chickens.

Interferons (IFNs) are essential components of the antiviral defense system of vertebrates. In mammals, functional receptors for type III IFN (lambda interferon [IFN-λ]) are found mainly on epithelial cells, and IFN-λ was demonstrated to play a crucial role in limiting viral infections of mucosal surfaces. To determine whether IFN-λ plays a similar role in birds, we produced recombinant chicken...

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses.

The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The expression of IFNλ4 is correlated with both poor spontaneous clearance of hepatitis C virus (HCV) and poor response to treatment with type I interferon. Here, we show that the IFNL4 gene encodes an active type III inter...

Interferon lambda 4 signals via the IFMλ receptor to regulate antiviral activity against HCV and coronaviruses

I have received the two reports on your paper, which I have provided below. Bottom line is that a lot of work would be needed for consideration at the EMBO Journal see referee #2. If you would be able to fully address the concerns raised with the inclusion of experimental data then we would be interested, but if you can't extend the analysis as needed then it is in your best interest to seek ra...

Polymorphic lambda calculus and subtyping

We present a denotational model for F<, the extension of second-order lambda calculus with subtyping defined in [Cardelli Wegner 1985]. Types are interpreted as arbitrary cpos and elements of types as natural transformations. We prove the soundness of our model with respect to the equational theory of F< [Cardelli et al. 1991] and show coherence. Our model is of independent interest, because it...

Metacircularity in the Polymorphic lambda-Calculus