A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7
نویسندگان
چکیده
منابع مشابه
Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
In mammalian cells, ceramide is synthesized in the endoplasmic reticulum and transferred to the Golgi apparatus for conversion to sphingomyelin. Ceramide transport occurs in a nonvesicular manner and is mediated by CERT, a cytosolic 68-kDa protein with a C-terminal steroidogenic acute regulatory protein-related lipid transfer (START) domain. The CERT START domain efficiently transfers natural D...
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The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes Sta...
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Interleukin 1 is the prototype of an inflammatory cytokine, and evidence suggests that it uses the sphingomyelin pathway and ceramide production to trigger mitogen-activated protein kinase (MAPK) activation and subsequent gene expression required for acute inflammatory processes. To identify downstream signaling targets of ceramide, a radioiodinated photoaffinity labeling analog of ceramide ([1...
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We have chosen Xenopus laevis as a model system to study how protein tyrosine phosphatases (PTPases) function in growth and development. As an initial step, we have previously isolated in a polymerase chain reaction (PCR)-based protocol cDNA fragments which correspond to sequences within the catalytic domains of PTPases (Yang, Q., and Tonks, N. K. (1993) Adv. Protein Phosphatases 7, 359-372). T...
متن کاملLipid Metabolism: Ceramide Transfer Protein Adds a New Dimension
Just as non-lipidologists were becoming reconciled to the complexities of networks of ceramide metabolism and the diverse roles of ceramide in cell regulation and membrane structure, a new study reveals a new layer of regulation of ceramide through the actions of a ceramide binding/transfer protein.
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2018
ISSN: 0022-2275
DOI: 10.1194/jlr.m082354