A simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent vapours.
نویسندگان
چکیده
منابع مشابه
A simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent vapours.
At a given external dose of an inhaled chemical the internal dose or the amount absorbed into the body varies depending on pulmonary ventilation and other physiological factors. Such variability is of concern in the development of biological indices of occupational exposure to organic solvent vapours. This paper discusses how physiological factors may influence the pharmacokinetic behaviour of ...
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[Physiological and environmental factors affecting biological monitoring of exposure to organic solvent vapors].
A review of the literature was made on the physiological and environmental factors affecting pharmacokinetic behavior of organic solvent vapors in relation to biological monitoring of exposure to organic solvents. Among the physiological factors the importance is attached to body build (body weight and body fat content), sex, and physical activity. Environmental factors are centered on cigarett...
متن کاملEffects of consumption of ethanol on the biological monitoring of exposure to organic solvent vapours: a simulation study with trichloroethylene.
This study illustrates possible influences of consumption of ethanol on the pharmacokinetic behaviour of inhaled trichloroethylene (TRI) in relation to biological monitoring of exposure. The results were obtained for a standard male worker of 70 kg by physiologically based pharmacokinetic modelling. Depending on the pattern of consumption of ethanol, enzyme inhibition or induction was assumed t...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1991
ISSN: 1351-0711
DOI: 10.1136/oem.48.5.342