A Single Transcription Factor Drives Toxoplasma gondii Differentiation
نویسندگان
چکیده
منابع مشابه
Dynamics of Toxoplasma gondii differentiation.
Parasite differentiation is commonly associated with transitions between complex life cycle stages and with long-term persistence in the host, and it is therefore critical for pathogenesis. In the protozoan parasite Toxoplasma gondii, interconversion between rapidly growing tachyzoites and latent encysted bradyzoites is accompanied by numerous morphological and metabolic adaptations. In order t...
متن کاملToxoplasma gondii
A total of 349 human serum samples were examined for anti-Toxoplasma antibodies by the Murex Single Use Diagnostic System (SUDS) qualitative screening test, indirect hemagglutination assay (IHA), and indirect immunofluorescence assay (IFA). Concordant results with SUDS and IHA were obtained for 91.9% of serum samples; 8.9% were SUDS+ and IHA-; none were SUDSand IHA+. Comparison of the SUDS assa...
متن کاملToxoplasma gondii
The performance of a direct agglutination test for the detection of toxoplasma specific IgG immunoglobulin was compared with that ofthe latex agglutination test. The direct agglutination test was less sensitive but more specific than the latex agglutination test. Quantitative results were not directly comparable, reflecting the different antibody profiles detected in each assay. The direct aggl...
متن کاملCyclic nucleotide signaling in Toxoplasma gondii bradyzoite differentiation.
The ability of Toxoplasma gondii tachyzoites to differentiate into latent bradyzoite forms is essential for pathogenesis of clinical disease. We examined the effects of cyclic nucleotides on T. gondii bradyzoite differentiation in vitro. Differentiation of tachyzoites to bradyzoites was measured in an immunofluorescence assay using ME49 or its clonal derivative PLK, two well-characterized T. go...
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Hammondia hammondi is a protozoan parasite that, until 1975, was misidentified as Toxoplasma gondii. Recently, the validity of H. hammondi has been questioned. In this article, the authors redescribe the parasite and its life cycle, provide accession numbers to its specimens deposited in a museum, and distinguish it structurally and biologically from T. gondii. Hammondia hammondi was found to b...
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ژورنال
عنوان ژورنال: Cell
سال: 2020
ISSN: 0092-8674
DOI: 10.1016/j.cell.2019.12.038