A Solvent?free, Catalyst?free Formal [3+3] Cycloaddition Dearomatization Strategy: Towards New Fluorophores for Biomolecules Labelling

Labelling Bacterial Nanocages with Photo‐switchable Fluorophores

The robustness and biocompatibility of bacterial nanocages holds promise for bio-nanotechnologies. The propensity of these nano-carriers to penetrate cells has been demonstrated, which calls for the development of tracking strategies, both in vitro and in vivo. Here, we label bacterial nanocages with photo-switchable fluorophores, to facilitate their imaging by super-resolution microscopy. We d...

Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines.

Ugi adducts derived from aromatic aldehydes may be converted to pyrrolines via addition of Michael acceptors under microwave irradiation. The reaction may proceed via unusual formation of azomethine ylides followed by a [3+2] cycloaddition using Michael acceptors.

An enantioselective organocatalytic oxidative dearomatization strategy.

The inherent reactivity and functionality stored within aromatic systems provide numerous possibilities for the synthesis of 3-D organic structures via dearomatization processes.1,2 Under oxidizing conditions, the dearomatization of orthoand para-substituted phenols forms cyclohexadienones,3 and these products have found widespread use in the chemical synthesis of natural products.4 Additionall...

a new approach to credibility premium for zero-inflated poisson models for panel data

هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...

Is Medical Application Software a New Strategy for Oncologists?