A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS

A Specific Complement-fixation Test for Infection with Poliomyelitis Virus

A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this...

A Complement Fixation Test for Poliomyelitis

A macroscopic (tube) complement fixation test for poliomyelitis, using infected tissue culture fluids, is described. The test was applied to 27 individuals with a clinical diagnosis of poliomyelitis. In 18 patients it was possible to make a laboratory diagnosis of poliomyelitis on the basis of a rise in complement-fixing antibody titer and in 4 others on the basis of a high stationary antibody ...

Complement Fixation Tests in Poliomyelitis **

Infection with poliomyelitis virus gives rise to complement-fixing (C-F) antibodies which may be detected with antigens prepared either from the brains of infected mice or tissue culture fluids, as shown with Type II by Casals et al."' and with all three types by Svedmyr et al.' These workers used sufficient antigen in each test to obtain maximum sensitivity. With this antigen concentration the...

Detection of rotavirus by Latex Agglutination Test (Rotales); Comparison with Electron Microscopy and Complement Fixation Test

Complement-fixation test for lymphogranuloma venereum in non-specific urethritis.

A report by Bedson (1950) had not shown such an association, nor was any such relationship noted between non-specific urethritis and the results of the complement-fixation test for enzootic abortion in ewes by Willcox and Stamp (1953). In the latter investigation some 323 complementfixation tests for enzootic abortion in ewes were performed on sera from 123 patients with present or past non-spe...