A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis
نویسندگان
چکیده
منابع مشابه
A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.
BACKGROUND Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in lung cancer metastasis. The class III deacetylase sirtuin 1 (SIRT1) possesses both pro- and anticarcinogenic properties. The role of SIRT1 in lung cancer EMT is largely undefined. METHODS The effect of SIRT1 on migration of lung cancer cells was evaluated by wound healing assay in vitro and metastasis assay in nude ...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2013
ISSN: 1460-2105,0027-8874
DOI: 10.1093/jnci/djt118