A Validated Liquid Chromatography-Tandem Mass Spectrometry Coupled with Liquid-Liquid Extraction for Indacaterol Quantitation in Human Plasma
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منابع مشابه
A Validated Liquid Chromatography-Tandem Mass Spectrometry Coupled with Liquid-Liquid Extraction for Indacaterol Quantitation in Human Plasma
Indacaterol is a recent ultra-long-acting inhaled β2-agonist bronchodilator. The current work validated an in-house developed high performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS) bioassay for indacaterol in human plasma. Ethyl acetate was used in a liquid-liquid extraction (LLE) method to extract indacaterol from plasma samples. A 200 μL of the mobile phase (water-meth...
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In previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. The aim of the current study was to develop a valid method using reversed-phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry to assay mebudipine in the human plasma. Separation was achieved on a Zorbax...
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In previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. The aim of the current study was to develop a valid method using reversed-phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry to assay mebudipine in the human plasma. Separation was achieved on a Zorbax...
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متن کاملLiquid chromatography-inductively coupled plasma mass spectrometry.
The technique of coupling liquid chromatography to inductively plasma mass spectrometry (ICP-MS) is reviewed. A brief introduction to the ICP-MS instrument is given as well as methods to couple the two analytical instruments together. The various types of LC that have been used with ICP-MS detection are discussed and advantages over traditional methods of detection are highlighted, such as the ...
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ژورنال
عنوان ژورنال: Advances in Pharmacology and Pharmacy
سال: 2015
ISSN: 2332-0036,2332-0044
DOI: 10.13189/app.2015.030203