Abnormality of Intracellular 5α-Dihydrotestosterone Binding in Simple Hypospadias: Studies on Equilibrium Steroid Binding in Sonicates of Genital Skin Fibroblasts
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چکیده
منابع مشابه
Intracellular and nuclear binding of [3H]dihydrotestosterone in cultured genital skin fibroblasts of patients with severe hypospadias.
Androgens stimulate the development and growth of the male external genitalia. Because hypospadias is the most common congenital defect of the male urethra and because in most cases the cause of this malformation is unknown, we examined the hypothesis that the etiology of the severe forms of this disorder, which is frequently associated with other genital anomalies, might be explained by recept...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1984
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198402000-00020