Absolute Configuration Determination from Low <i>ee</i> Compounds by the Crystalline Sponge Method. Unusual Conglomerate Formation in a Pre?Determined Crystalline Lattice

When chiral compounds with low enantiomeric excess (ee, R:S=m:n) were absorbed into the void of crystalline sponge (CS), enantiomerically pure [(R)m(S)n] composites formed, changing centrosymmetric space group non-centrosymmetric one. The absolute configuration analyte was elucidated a reasonable Flack (Parsons) parameter value. This phenomenon is characteristic to “post-crystallization” in pre-determined CS lattice, seldom found common crystallization where lattice defined by an itself. results highlight potential method for determination ee samples, often encountered situation asymmetric synthesis studies.