Absorption, Distribution and Excretion of .BETA.-Cyclodextrin and Glucosyl-.BETA.-cyclodextrin in Rats.
نویسندگان
چکیده
منابع مشابه
Deprotonation of beta-cyclodextrin in alkaline solutions.
Variable pH (13)C NMR and (1)H NMR spectroscopic studies of the beta-cyclodextrin (beta-CD) in alkaline aqueous solutions revealed that beta-CD does not deprotonate at pH<12.0. Further increase in solution pH results in the deprotonation of OH-groups adjacent to C-2 and C-3 carbon atoms of beta-CD glucopyranose units, whereas the deprotonation of OH-groups adjacent to C-6 carbon atoms is expres...
متن کاملMolecular modelling and 1H-NMR: ultimate tools for the investigation of tolbutamide: beta-cyclodextrin and tolbutamide: hydroxypropyl-beta-cyclodextrin complexes.
A structural study of the inclusion compound of tolbutamide (TBM) with beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was attempted by means of 1H-nuclear magnetic resonance (1H-NMR) experiments and computer molecular modelling. To establish the stoichiometry and stability constant of the beta-CD:TBM complex, the continuous variation method was used. The presence o...
متن کاملStudy of inclusion complex of beta-cyclodextrin and nitrobenzene.
beta-cyclodextrin can react with nitrobenzene to form an inclusion complex which is characterized by (1)H NMR and powder X-ray diffractometry. The ratio of beta-CD to NB in inclusion complex is determined as 1:1. At 25 degrees C, the dissociated constant, K(D), of the inclusion complex is measured as 6.5 x 10(-3) M in neutral solution (pH=7.0), but in alkali (pH=13.5), K(D) is 3.2 x 10(-2) M wh...
متن کاملComplexation study of diclofenac with beta-cyclodextrin and spectrofluorimetric determination.
The inclusional complexation between the anti-inflammatory pharmaceutical diclofenac and beta-cyclodextrin (beta-CD) was studied by potentiometry, spectrophotometry and spectrofluorimetry, in both acid and neutral pH. Guest-host 1:1 stoichiometries for the complexes in both media were determined, and their equilibrium constants were calculated. The values obtained from the different methods use...
متن کاملPhysicochemical and structural characterization of quercetin-beta-cyclodextrin complexes.
Quercetin is a bioactive flavonoid widely used as a health supplement. Being sparingly soluble and chemically unstable in aqueous intestinal fluids, quercetin is poorly absorbed orally. This study aimed to investigate the effects of three beta-cyclodextrins, namely, unsubstituted beta-cyclodextrin (beta-CD), hydroxypropyl-beta-cyclodextrin (HP-beta-CD), and sulfobutyl ether beta-cyclodextrin (S...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1996
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.19.1068