Aconitum and Delphinium sp. alkaloids as antagonist modulators of voltage-gated Na+ channels

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Aconitum and Delphinium sp. alkaloids as antagonist modulators of voltage-gated Na+ channels: AM1/DFT electronic structure investigations and QSAR studies

Early pharmacological studies of Aconitum and Delphinium sp. alkaloids suggested that these neurotoxins act at site 2 of voltage-gated Na(+) channel and allosterically modulate its function. Understanding structural requirements for these compounds to exhibit binding activity at voltage-gated Na(+) channel has been important in various fields. This paper reports quantum-chemical studies and qua...

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ژورنال

عنوان ژورنال: Computational Biology and Chemistry

سال: 2008

ISSN: 1476-9271

DOI: 10.1016/j.compbiolchem.2007.10.003