Activated CaMKIIα Binds to the mGlu5 Metabotropic Glutamate Receptor and Modulates Calcium Mobilization
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چکیده
منابع مشابه
Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization.
Some, perhaps all, G protein-coupled receptors form homo- or heterodimers. We have shown that metabotropic glutamate receptors are covalent dimers, held together by one or more disulfide bonds near the N terminus. Here we report how mutating cysteines in this region affect dimerization and function. Covalent dimerization is preserved when cysteines 57, 93, or 99 are mutated but lost with replac...
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Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicyclic dihydronaphthyridinone was identified. We describe further refinements leading to both dihydronaphthyridinone and tetrahydronaphthyridine mGlu5 P...
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Coopman, K., Bradley, S.J., Wilkinson, G.F. and Willars, G.B. G-protein coupling and glucagonlike peptide-1 signalling in recombinant cell-lines. 2 Focused Meeting Cell Signalling 16-17 April 2007. Poster Presentation. Bradley, S.J., Howes, C.M., Wood, M.D. and Challiss, R.A.J. Effects of Positive Allosteric Modulators of the mGlu5 Receptor on Oscillatory Patterns of Ca 2+ Signalling. Metabotro...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2018
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.118.113142