Activated prothrombin complex concentrate for dabigatran-associated bleeding
نویسندگان
چکیده
منابع مشابه
More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin complex concentrate or recombinant factor VIIa than by four-factor prothrombin complex concentrate.
The number of patients on antithrombotic treatment due to atrial fibrillation and venous thromboembolism is increasing fast due to an aging population. A growing proportion will be treated with novel oral anticoagulants, the first in clinical use was the direct oral thrombin inhibitor dabigatran (Pradaxa®). A small percentage of the patients on dabigatran will experience serious bleeding or be ...
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Gilles Corbonnois1,2*; Michèle Martin2,3*; Marie Hacquard3; Bruno Levy2,4; Paul Michel Mertes1,2; Thomas Lecompte2,3,5**; Gérard Audibert1,2** 1University Hospital of Nancy, Department of Anaesthesia and Intensive Care Medicine, Nancy, France; 2INSERM 961, Contrat Avenir INSERM, Nancy, France; 3University Hospital of Nancy, Haematology Laboratory – Haemostasis, Nancy, France; 4Hospital Universi...
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BACKGROUND Apixaban is a direct factor Xa inhibitor approved for the treatment and prevention of thromboembolic disease. There is a lack of data regarding its reversal in cases of acute bleeding or prior to emergency surgery that needs addressing. OBJECTIVES This study assessed whether a four-factor prothrombin complex concentrate (4F-PCC; Beriplex(®) /Kcentra(®) , CSL Behring) can effectivel...
متن کاملProthrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital
INTRODUCTION Major blood loss can often be life-threatening and is most commonly encountered in the settings of surgery and trauma. Patients receiving anticoagulant therapy are also at increased risk of bleeding. We investigated the use of a prothrombin complex concentrate (PCC; Beriplex P/N, CSL Behring, Marburg, Germany) to treat severe bleeding in a variety of settings: cardiac surgery, warf...
متن کاملSafety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery.
BACKGROUND Bleeding after cardiac surgery requiring surgical reexploration and blood component transfusion is associated with increased morbidity and mortality. Although prothrombin complex concentrate (PCC) has been used satisfactorily in bleeding disorders, studies on its efficacy and safety after cardiopulmonary bypass are limited. METHODS Between January 2005 and December 2013, 3454 conse...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2013
ISSN: 0007-1048
DOI: 10.1111/bjh.12620