Active oxygen species in DNA damage induced by carcinogenic metal compounds.
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چکیده
منابع مشابه
Active oxygen species in DNA damage induced by carcinogenic metal compounds.
Some carcinogenic metal compounds [chromate(VI), Fe(III) nitrilotriacetate, cobalt(II), and nickel(II)[ induced formation of various oxygen radical species in the presence of hydrogen peroxide. These oxygen radicals were suggested to give different kinds of site-specific DNA damage; 8-hydroxyl-2'-deoxyguanosine formation is included in the DNA damage. Using pulsed-field gel electrophoresis, nic...
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Some metal compounds, including arsenic, beryllium, cadmium, chromium and nickel have long been recognized as human and animal carcinogens, while for other as antimony, cobalt, lead and vanadium their carcinogenic action are probable or possible. Except chromium (VI), carcinogenic metals are only weak mutagens in mammalian cells and often inactive in bacterial assays. Since the mutagenicity in ...
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Most arylamines are pro-carcinogens, and require metabolic activation to yield ultimate carcinogen metabolites. O-Acetylation of the N-hydroxy form of an arylamine yields an acetoxyarylamine, which can form a highly reactive arylnitrenium ion, the ultimate metabolite responsible for DNA adduct formation. However, we demonstrate here that the N-hydroxy and nitroso forms of arylamines can also in...
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Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nucleotide excision repair, even though they affect different steps of the respe...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1994
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.94102s317