Adaptive Immune Response against Hepatitis C Virus
نویسندگان
چکیده
منابع مشابه
Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response
Autophagy is a catabolic process that is important for maintaining cellular homeostasis. This pathway in hepatocytes is stimulated and controlled by the hepatitis C virus (HCV)-upon infection-to promote its own replication. HCV induces autophagy indirectly and directly through different mechanisms and temporally controls the autophagic flux. This enables the virus to maximize its replication an...
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A hepatitis C virus (HCV) E2 variant encompassing amino acids 458 to 680 was expressed in Escherichia coli. The recombinant product (His-E2680) was immunoidentified as a 30-kD protein using the serum from a patient with chronic hepatitis C, and was purified using Ni-NTA chelate chromatography. When HCV-positive human sera were tested with the His-E2680 protein, 39% of them showed anti-E2 reacti...
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Hepatitis C virus (HCV) is a major human pathogen causing mild to severe liver disease worldwide. This positive strand RNA virus is remarkably efficient at establishing chronic infections. Although a high rate of genetic variability may facilitate viral escape and persistence in the face of Ag-specific immune responses, HCV may also encode proteins that facilitate evasion of immunological surve...
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To study the effect of genetic immunization on transgenic expression of hepatitis C virus (HCV) proteins, we evaluated the immunological response of HCV transgenic mice to HCV expression plasmids. FVB/n transgenic mice expressing HCV structural proteins (core, E1, and E2) and wild-type (WT) FVB/n mice were immunized intramuscularly with plasmids expressing core (pHCVcore) or core/E1/E2 (pHCVSt)...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21165644