Adaptive Methods: When and How Should They be Used in Clinical Trials?
نویسندگان
چکیده
منابع مشابه
Adaptive Methods: When and How Should They be Used in Clinical Trials?
– Adaptive clinical trial designs are defined as designs that use data cumulated during trial to possibly modify certain aspects without compromising the validity and integrity of the said trial. Compared to more traditional trials, in theory, adaptive designs allow the same information to be generated but in a more efficient manner. The advantages and limits of this type of design together wit...
متن کاملRandomized clinical trials: how long should they last?
Well-conducted randomized clinical trials (RCT) are essential for the objective assessment of the value of new diagnostic or therapeutic medical interventions. They also will give us information about the effect of the intervention on cost and quality of life. Although the RCT was introduced 50 years ago, the requirements to ensure the best possible quality are continuously scrutinized.1–4 That...
متن کاملCancer antigens: how specific should they be?
INTRODUCTION Four years have passed since the last comprehensive meeting was held to discuss directions in which the immunological discipline might contribute to an understanding of cancer problems, and it should be a measure of our progress to compare the content of the papers presented at that meeting with those delivered here. The earlier meeting did not have precisely the same objectives as...
متن کاملQuantity discounts; how big should they be?
While most market-oriented pricing schemes include offers of quantity discounts, their size is generally decided on arbitrarily. This article discusses the various possible marketing objectives of quantity discounts and argues that valid methods for calculating appropriate schedules should be linked to these objectives. Using a specific case study, the practical application of this approach is ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Therapies
سال: 2011
ISSN: 0040-5957
DOI: 10.2515/therapie/2011044