Additive-Manufactured Gyroid Scaffolds of Magnesium Oxide, Phosphate Glass Fiber and Polylactic Acid Composite for Bone Tissue Engineering

Composites of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) show potential for bone tissue engineering scaffolds, due to their ability release Ca, P, Mg during degradation, thus promoting the repair. Nevertheless, degradation tends acidify surrounding aqueous environment, which may adversely affect viability bone-forming activities osteoblasts. In this work, MgO was investigated as a neutralizing agent. Porous network-phase gyroid scaffolds were additive-manufactured using four different materials: PLA, MgO/PLA, PGF/PLA, (MgO + PGF)/PLA. The addition PGF enhanced compressive properties resultant comparably strong stiff with human trabecular bone. While PGF/PLA composite induced considerable acidity in media intensified return, PGF)/PLA maintained neutral pH close physiological environment. experiment results indicated possible mechanism agent: local buffered reacted acidic products thereby inhibiting from being an scaffold appears be candidate engineering.