Addressing Missing Data in Clinical Trials
نویسندگان
چکیده
منابع مشابه
The prevention and treatment of missing data in clinical trials.
Missing data have seriously compromised inferences from clinical trials, yet the topic has received little attention in the clinical-trial community.1 Existing regulatory guidances2-4 on the design, conduct, and analysis of clinical trials have little specific advice on how to address the problem of missing data. A recent National Research Council (NRC) report5 on the topic seeks to address thi...
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Guideline on Missing Data in Confirmatory Clinical Trials Discussion in the Efficacy Working Party June 1999/ November 2000 Transmission to CPMP January 2001 Released for consultation January 2001 Deadline for Comments April 2001 Discussion in the Efficacy Working Party October 2001 Transmission to CPMP November 2001 Adoption by CPMP November 2001 Draft Rev. 1 Agreed by Efficacy Working Party A...
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OBJECTIVE Missing outcome data are a common problem in clinical trials and systematic reviews, as it compromises inferences by reducing precision and potentially biasing the results. Systematic reviewers often assume that the missing outcome problem has been resolved at the trial level. However, in many clinical trials a complete case analysis or suboptimal imputation techniques are employed an...
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A LTHOUGH RANDOMIZED TRIALS HAVE BEEN CON ducted for several decades now, some aspects of their analysis remain contentious. Two such is sues are what to do about trial participants who do not adhere to the protocol (for example, if they do not re ceive the intended treatment) and how to deal with those for whom outcome assessments are missing (for example, because they are lost to followup...
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In most clinical trials, some patients do not complete their intended follow-up according to protocol, for a variety of reasons, and are often described as having 'dropped out' before the conclusion of the trial. Their subsequent measurements are missing, and this makes the analysis of the trial's repeated measures data more difficult. In this paper we briefly review the reasons for patient dro...
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ژورنال
عنوان ژورنال: Annals of Internal Medicine
سال: 2011
ISSN: 0003-4819
DOI: 10.7326/0003-4819-154-2-201101180-00010