Adenosine A1 receptor mediates delayed cardioprotective effect of sildenafil in mouse
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چکیده
منابع مشابه
Adenosine A(1) receptor mediates delayed cardioprotective effect of sildenafil in mouse.
Sildenafil induces powerful cardioprotection against ischemia/reperfusion (I/R) injury. Since adenosine is known to be a major trigger of ischemic preconditioning, we hypothesized that A(1) adenosine receptor (A(1)AR) activation plays a role in sildenafil-induced cardioprotective signaling. Adult male C57BL wild-type (WT) mice or their corresponding A(1)AR knockout (A(1)AR-KO) mice were treated...
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There has been controversy regarding whether ATP-sensitive potassium channel activation protects hearts through adenosine A1 receptor activation or the converse. We addressed this issue by determining the effect of the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) on the cardioprotective activity of the ATP-sensitive potassium channel opener bimakalim. In isolated ...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2007
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2007.08.014