ADENOSINETRIPHOSPHATE-CREATINE TRANSPHOSPHORYLASE
نویسندگان
چکیده
منابع مشابه
Kinetic properties and equilibrium constant of the adenosine triphosphate-creatine transphosphorylase-catalyzed reaction.
catalyzed by adenosine triphosphate-creatine transphosphorylase can be described by a reasonable kinetic scheme. It was shown that MgATPzis the “true substrate,” that the Michaelis constant is the dissociation constant of the enzyme-substrate complex, and that the pH-activity curve resembles a single ionization curve with pK N 6.5. It was of interest to study the kinetics of the reverse process...
متن کاملThe enzymatic activity and inhibition of adenosine 5'-triphosphate-creatine transphosphorylase.
From our earlier rate measurements (l), it was not possible to develop a satisfactory kinetic scheme accounting for the dependence of reaction rate on the concentration of certain ions, such as Mg++ and Hf. Recently, however, we have found (2) that some of the anions which we were inadvertently introducing in the earlier work (e.g. in varying the concentration of Mg++ with the use of magnesium ...
متن کاملStudies on adenosine triphosphate transphosphorylases. II. Amino acid composition of adenosine triphosphate-creatine transphosphorylase.
Some of the physical and chemical properties of crystalline adenosine triphosphate-creatine transphosphorylase from rabbit muscle (1) have been previously described (2). In 1956, Friedberg reported on the amino acid composition of this enzyme (3). His data, however, were derived from analyses of only two samples hydrolyzed for the same time interval. Preliminary amino acid analyses from this la...
متن کاملAn Adenosinetriphosphate-Activated Hemolytic System
Lysis of human red cells in vitro by an enzyme obtained from rabbit red cell hemolysates and the inhibition of this lytic activity by human stroma have been shown to require Mg(++) and ATP, and ATP utilization has been demonstrated in both reactions. We find that sodium or potassium ions are also required for the lytic phenomenon and that they enhance the inhibition. The rate of hemolysis is no...
متن کاملMg spin affects adenosinetriphosphate activity
The Schlegel-Frisch ab initio molecular dynamics (ADMP) (DFT:B3LYP), T = 310 K, is used to study complexation between adenosinetriphosphate (ATP), ATP subsystem, and magnesium cofactor [Mg(H2O)6] , Mg subsystem, in a water pool, modeled with 78 water molecules, in singlet (S) and triplet (T) states. The computations prove that the way of ATP cleavage is governed by the electron spin of Mg. In t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1954
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65434-1