Adherence to Single-Pill Versus Free-Equivalent Combination Therapy in Hypertension

Poor adherence to antihypertensive therapy is a major cause of poor blood pressure (BP) control in patients with hypertension. Regimen simplification may improve and BP control. This systematic review assessed whether single-pill combination (SPC) led improved adherence, persistence, better compared free-equivalent (FEC) PubMed, Medline, Embase, the Cochrane Library were searched until July 2020, addition manual searching relevant congress abstracts from 2014 2020 for studies including adults hypertension aged ≥18 years receiving SPC or FEC measuring any following: reductions systolic and/or diastolic BP. Adherence persistence summarized narrative analysis; direct pair-wise meta-analysis was conducted compare versus using fixed-effect random-effects models. Following screening, 44 included. The majority (18 23) showed significantly SPCs FECs. Overall, 16 measured which 14 that had less likely discontinue than Systolic (mean difference, −3.99 [95% CI, −7.92 −0.07]; P =0.05) (−1.54 −2.67 −0.41]; =0.0076) both reduced at week 12. leads lead