Adipose tissue and insulin resistance in obese
نویسندگان
چکیده
منابع مشابه
Association of some dietary intakes, anthropometric measurements and insulin resistance with the relative P53 gene expression in visceral and subcutaneous adipose tissue in obese, and non-obese subjects
Background and Objectives: The P53 is one of the genes involved in weight management. This study investigated associations of dietary intakes, anthropometric measurements and insulin resistance with relative P53 gene expressions. Materials & Methods: Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were collected from 151 individuals, aging nearly 40 years, who underwent el...
متن کاملAdipose Tissue Inflammation and Insulin Resistance
A sustained increase in body mass, particularly fat mass, an unhealthy diet and a sedentary lifestyle trigger metabolic alterations such as metabolic syndrome, obesity, and type 2 diabetes mellitus (2DM). These metabolic conditions increase the cardiovascular disease risks and have become epidemic public health problems (Grundy 2002). Individuals who are overweight and obese are associated with...
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Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose...
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Obesity is associated with insulin resistance. Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism ...
متن کاملAttenuated Pik3r1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice
Obese white adipose tissue (AT) is characterized by large-scale infiltration of proinflammatory macrophages, in parallel with systemic insulin resistance; however, the cellular stimulus that initiates this signaling cascade and chemokine release is still unknown. The objective of this study was to determine the role of the phosphoinositide 3-kinase (PI3K) regulatory subunits on AT macrophage (A...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2021
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2021.111315