Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations
نویسندگان
چکیده
منابع مشابه
Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations.
We describe an extension of Risch's [(1990a,b) Am J Hum Genet 46:222-228, 229-241] method of linkage detection and exclusion for complex genetic traits. The method uses interval mapping to infer disease locus identity-by-descent (IBD) sharing for affected sib pairs (ASPs) based on marker information for the ASP and other genotyped family members. The method is likelihood based, and makes use of...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 1996
ISSN: 0741-0395,1098-2272
DOI: 10.1002/(sici)1098-2272(1996)13:2<117::aid-gepi1>3.0.co;2-5