Age-Dependent Kinetics and Metabolism of Dichloroacetate: Possible Relevance to Toxicity

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

Dichloroacetate (DCA) is an investigational drug for certain metabolic diseases. It is biotransformed principally by the zeta-1 family isoform of glutathione transferase (GSTz1), also known as maleylacetoacetate isomerase (MAAI), which catalyzes the penultimate step in tyrosine catabolism. DCA causes a reversible peripheral neuropathy in several species, including humans. However, recent clinic...

Regulator-dependent haemopoiesis and its possible relevance to leukemogenesis.

surveying the relevance of proportions to the content of quran verses

چکیده : قرآن چشمه سار زلال هدایتی است که از سوی خداوند حکیم نازل شده تا بشر را به سر منزل کمال برساند. و در این راستا از شیوه های گوناگون بیانی خطابی و بلاغی استفاده کرده تا با فطرت زیبا طلب انسان درآمیزد و اورا مقهور خویش ساخته، به سوی کمالات سوق دهد.ازجمله جنبه های بارز اعجاز بیانی قرآن وجود فواصل در پایان آیات است که کار برد سجع و قافیه در کلام بشر شبیه آن است. برخی ازعلمای سلف تفاوت هایی ب...

Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy.

Previous studies in experimental animals and patients have suggested a circadian variation in host toxicity following administration of 5-fluorodeoxyuridine (FdUrd) although the biochemical mechanisms are not fully understood. Thymidine kinase (TK; EC 2.7.1.21), the initial enzyme in the thymidine-phosphorylation pathway, is the first enzyme in the anabolism of FdUrd. Dihydropyrimidine dehydrog...

Relationship between Circadian-dependent Toxicity of 5-Fluorodeoxyuridine and Circadian Rhythms of Pyrimidine Enzymes: Possible Relevance to Fluoropyrimidine Chemotherapy1

Previous studies in experimental animals and patients have suggested a circadian variation in host toxicity following administration of 5-fluorodeoxyuridine (Fdl'rd) although the biochemical mechanisms are not fully understood. Thymidine kinase (TK: EC 2.7.1.21), the initial enzyme in the thymidine-phosphorylation pathway, is the llrst enzyme in the anaholism of Kdl'rd. Dihydropyrimidine dehydr...