Age-related changes of choroid plexus morphology, vascularization and epithelial proliferation

The choroid plexus (ChP) is essential for brain homeostasis by regulating the secretion of cerebrospinal fluid (CSF). Despite a substantial body work on pathologically alterations ChP, there lack data concerning naturally occurring morphological changes asso-ciated with ageing. In this study, we investigated 30 human ChP tissue samples that were divided into 3 groups according to age. Morphometric analysis psammoma bodies (PBs) hematoxylin and eosin (H&E)-stained immunohistochemical performed (using antibodies transmembrane phosphoglycoprotein protein CD34 nuclear Ki-67). Amyloid deposits detected using Congo red staining. Middle-aged older individuals exhibited significantly higher numerical density (ndPB) mostly as increased immature forms, which led us question proposed nomenclature. proliferation rate epithelium did not show significant difference between groups. vascular area was markedly decreased accompanied amyloid deposition in blood vessel walls. While limited middle-sized vessels middle-aged group, group also present around small vessels. identified major ageing provide further understanding disfunctions blood-cerebrospinal barrier underlie neurodegenerative disorders.