Age-Related Skeletal Muscle Dysfunction Is Aggravated by Obesity: An Investigation of Contractile Function, Implications and Treatment

Obesity is a global epidemic and coupled with the unprecedented growth of world’s older adult population, growing number individuals are both old obese. Whilst ageing obesity associated an increased prevalence chronic health conditions substantial economic burden, evidence suggests that coincident effects exacerbate negative outcomes. A significant contributor to such detrimental may be reduction in contractile performance skeletal muscle, given poor muscle function related disease, quality life all-cause mortality. independently on have been investigated, combined yet thoroughly explored. Given importance whole-body physical function, present study sought provide review literature to: (1) summarise effect age-induced function; (2) understand whether similar young muscle; (3) consider consequences these changes functional performance; (4) outline important future work along potential for targeted intervention strategies mitigate effects.