Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: Possible involvement of mitochondrial S-adenosylmethionine transport
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چکیده
منابع مشابه
S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver.
An early event that occurs in response to alcohol consumption is mitochondrial dysfunction, which is evident in changes to the mitochondrial proteome, respiration defects, and mitochondrial DNA (mtDNA) damage. S-adenosylmethionine (SAM) has emerged as a potential therapeutic for treating alcoholic liver disease through mechanisms that appear to involve decreases in oxidative stress and proinfla...
متن کاملS-Adenosylmethionine Prevents Chronic Alcohol-Induced Mitochondrial Dysfunction in Rat Liver
An early event that occurs in response to alcohol consumption is mitochondrial dysfunction, which is evident in changes to the mitochondrial proteome, respiration defects, and mtDNA damage. S-Adenosylmethionine (SAM) has emerged as a potential therapeutic for treating alcoholic liver disease through mechanisms that appear to involve decreases in oxidative stress and pro-inflammatory cytokine pr...
متن کاملPlasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats.
OBJECTIVE The aim of this study was to evaluate plasma homocysteine (Hcy), malondialdehyde (MDA), glutathione (GSH) levels, glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) activities and liver tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) levels in control and vitamin B6-deficient rats. MATERIALS AND METHODS Thirty-two male rats with a weight of 65-75 ...
متن کاملAltered Levels of S-Adenosylmethionine and S-Adenosylhomocysteine in the Brains of L-Isoaspartyl
L-Isoaspartyl (D-aspartyl) O-methyltransferase (PCMT1) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form. In the course of this reaction, PCMT1 converts the methyl donor S-adenosylmethionine (AdoMet) to S-adenosylhomocysteine (AdoHcy). Due to the high level of activity of this enzyme, particularly in the brai...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2007
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2007.05.005