Alginate Modification and Lectin-Conjugation Approach to Synthesize the Mucoadhesive Matrix

Alginates are natural anionic polyelectrolytes investigated in various biomedical applications, such as drug delivery, tissue engineering, and 3D bioprinting. Functionalization of alginates is one possible way to provide a broad range requirements for those applications. A techniques, including esterification, amidation, acetylation, phosphorylation, sulfation, graft copolymerization, oxidation reduction, have been implemented this purpose. The rationale behind these investigations often the combination modified with different molecules. Particularly promising lectin conjugate macromolecules lectin-mediated which enhance bioavailability active ingredients on specific site. Most interesting application alginate derivatives, because more resistant acidic enzymatic degradation. This review will report recent progress modification conjugation, focusing alginate-lectin proposed matrix mucoadhesive delivery provides new perspective future studies conjugation methods.