Alopecia after injection of ATX-101 for reduction of submental fat
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Alopecia after injection of ATX-101 for reduction of submental fat
BAs: Bile acids DCA: deoxycholic acid FDA: Food and Drug Administration INTRODUCTION Bile acids (BAs) are endogenously produced cholesterol derivatives that are found predominantly in bile and play a key role in lipid digestion. The surfactant activity of BAs is responsible for fat emulsification and subsequent solubilization, a process that is requisite for intestinal lipid absorption. Deoxych...
متن کاملAbstract: Alopecia in Male Patients Treated with ATX-101 (Deoxycholic Acid) for Submental Fullness
METHODS: Study subjects were at least 18 years of age and had moderate (GLS=2) to severe (GLS=3) glabellar lines at maximum frown, on the 4-point photonumeric Glabellar Line Scale (GLS, 0=no lines, 1=mild, 2=moderate, 3=severe). Subjects were randomly assigned in a 3:1 ratio to receive a single treatment (0.1 mL injected into each of 5 target sites in the glabellar region) of either DWP450 (tot...
متن کاملAbstract: Novel Expanded Safe Zone System for Treatment of Submental Fullness with ATX-101 (Deoxycholic Acid)
RESULTS: 264 responses were received. Averaged scores across the 10 survey patients produced a value for each appearance or personality trait. In 10 of 11 categories (symmetry, youthfulness, facial harmony, likeability, trustworthiness, confidence, femininity, attractiveness, approachability, and intelligence), the post-operative photo was significantly favorable compared to the preoperative ph...
متن کاملReduction of unwanted submental fat with ATX-101 (deoxycholic acid), an adipocytolytic injectable treatment: results from a phase III, randomized, placebo-controlled study*
BACKGROUND Unwanted submental fat (SMF) is aesthetically unappealing, but methods of reduction are either invasive or lack evidence for their use. An injectable approach with ATX-101 (deoxycholic acid) is under investigation. OBJECTIVES To evaluate the efficacy and safety of ATX-101 for the reduction of unwanted SMF. METHODS In this double-blind, placebo-controlled, phase III study, 363 pat...
متن کاملAbstract: Implantable Deferoxamine Facilitates Non-Vascularized Grafting in Irradiated Bone
1. Kythera Biopharmaceuticals I. Dermatologic and ophthalmic drugs advisory committee briefing document: ATX-101 (deoxycholic acid) injection. https:// www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DermatologicandOphthalmicDrugsAdvisoryCommittee/UCM436604.pdf. Accessed February 26, 2017. 2. Dayan SH, Humphrey S, Jones DH, et al. Overview of ATX-101 (Deoxycholic Acid ...
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ژورنال
عنوان ژورنال: JAAD Case Reports
سال: 2017
ISSN: 2352-5126
DOI: 10.1016/j.jdcr.2017.02.021