alpha-Adrenoceptor-Mediated Modulation of 5-HT2 Receptor Agonist Induced Impulsive Responding in a 5-Choice Serial Reaction Time Task
نویسندگان
چکیده
منابع مشابه
The 5-choice serial reaction time task: a task of attention and impulse control for rodents.
This protocol describes the 5-choice serial reaction time task, which is an operant based task used to study attention and impulse control in rodents. Test day challenges, modifications to the standard task, can be used to systematically tax the neural systems controlling either attention or impulse control. Importantly, these challenges have consistent effects on behavior across laboratories i...
متن کاملSerotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task
Executive functions are an emerging propriety of neuronal processing in circuits encompassing frontal cortex and other cortical and subcortical brain regions such as basal ganglia and thalamus. Glutamate serves as the major neurotrasmitter in these circuits where glutamate receptors of NMDA type play key role. Serotonin and dopamine afferents are in position to modulate intrinsic glutamate neur...
متن کاملMeasuring Attention in Rodents: Comparison of a Modified Signal Detection Task and the 5-Choice Serial Reaction Time Task
Neuropsychiatric research has utilized cognitive testing in rodents to improve our understanding of cognitive deficits and for preclinical drug development. However, more sophisticated cognitive tasks have not been as widely exploited due to low throughput and the extensive training time required. We developed a modified signal detection task (SDT) based on the growing body of literature aimed ...
متن کاملRole of endocannabinoids in 5-HT2 receptor-mediated effects.
Endocannabinoids are lipid retrograde messengers that can be released by postsynaptic depolarization and/or activation of certain metabotropic receptors. We review a recent report that activation of metabotropic 5-HT2 receptors by endogenous serotonin induces the release of endocannabinoids in the olivary nucleus and suppresses glutamatergic input through a presynaptic action. This serotonin-en...
متن کاملEffects of 5-ht2 Receptor Ligands on Tail Pinch-induced Stress Responding and Open Field Behavior
...............................................................................................ii
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacology and Toxicology
سال: 2003
ISSN: 0901-9928,1600-0773
DOI: 10.1034/j.1600-0773.2003.920504.x