Alpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 Myoblasts
نویسندگان
چکیده
Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water. We determined the impact of on Nrf-2, peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), citrate synthase (CS) activity C2C12 myoblasts. was titrated to three concentrations (PQQ) (10 nM, 100 1000 nM) treated for 48 h. Nrf-2 PGC-1α levels were measured using Western blot analysis. CS according previously described methods. Treatment significantly increased protein myoblasts, with no change CS. For values both nM (p = 0.046) 0.011) higher than control. PGC-1α, 0.039) 0.017) In small human pilot study, subjects consumed product daily four weeks, adverse effects, some noted as “responders” treatment. can increase concentration-dependent manner. Healthy men women who ingest do so without effects.
منابع مشابه
Levels of pyrroloquinoline quinone in various foods.
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The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes.
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ژورنال
عنوان ژورنال: Processes
سال: 2023
ISSN: ['2227-9717']
DOI: https://doi.org/10.3390/pr11072011