Altering the Tropism of Lentiviral Vectors through Pseudotyping
نویسندگان
چکیده
منابع مشابه
Beta thalassemia gene therapy using lentiviral vectors
Recent years, allogeneic bone marrow transplantation (BMT) has proved to be the successful cure for patients with thalassemia major, however this is restricted due to limited matched-related donor. Its complications include chronic graft-versus-host disease in 5-8% of patients. So, a molecular approach, such as gene therapy for direct normal beta globin gene transmission, seems quite promising ...
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A significant challenge in modern clinical medicine is that despite the existence of genetic therapies, lack of techniques to deliver them to the body remains a major roadblock. Viral vectors, benign vehicles for therapeutic delivery produced by removing the reproductive and virulence capacities of wild-type viruses, address this obstacle [1]. Unfortunately, if there is no naturally-occurring v...
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Adenoviral vectors (AVVs) and lentiviral vectors (LVVs) are highly useful research tools which can be used to investigate the function of specific cell phenotypes in the brain. The transductional tropism of viral vectors has a critical impact upon the transgene expression in different brain areas. This largely depends on the properties of the viral particles, which for AVVs are most commonly an...
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In this report it is demonstrated for the first time that rabies-G envelope of the rabies virus is sufficient to confer retrograde axonal transport to a heterologous virus/vector. After delivery of rabies-G pseudotyped equine infectious anaemia virus (EIAV) based vectors encoding a marker gene to the rat striatum, neurons in regions distal from but projecting to the injection site, such as the ...
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BACKGROUND Outbreaks of the Chikungunya virus (CHIKV) infection has been documented in over 40 countries, resulting in clinical symptoms characterized by fever and joint pain. Diagnosing CHIKV in a clinical lab setting is often omitted because of the high lab safety requirement. An infection system that mimics CHIKV infection will permit clinical evaluation of the production of neutralizing ant...
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ژورنال
عنوان ژورنال: Current Gene Therapy
سال: 2005
ISSN: 1566-5232
DOI: 10.2174/1566523054546224