Alternative splicing and bioinformatic analysis of human U12-type introns
نویسندگان
چکیده
منابع مشابه
Alternative splicing and bioinformatic analysis of human U12-type introns
U12-type introns exist, albeit rarely, in a variety of multicellular organisms. Splicing of U12 intron-containing precursor mRNAs takes place in the U12-type spliceosome that is distinct from the major U2-type spliceosome. Due to incompatibility of these two spliceosomes, alternative splicing involving a U12-type intron may give rise to a relatively complicated impact on gene expression. We stu...
متن کاملAlternative splicing of U12-type introns.
Precise removal of introns from metazoan precursor mRNAs is critical for gene expression. Nevertheless, alternative splicing provides a means for higher eukaryotes to increase genomic complexity and proteome diversity and to regulate certain cellular functions. The presence of rare U12-type pre-mRNA introns in eukaryotic genomes further complicates splicing events. In this review, we discuss th...
متن کاملU12-type Spliceosomal Introns of Insecta
Most of eukaryotic genes are interrupted by introns that need to be removed from pre-mRNAs before they can perform their function. This is done by complex machinery called spliceosome. Many eukaryotes possess two separate spliceosomal systems that process separate sets of introns. The major (U2) spliceosome removes majority of introns, while minute fraction of intron repertoire is processed by ...
متن کاملAberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
Somatic mutations in the spliceosome gene ZRSR2-located on the X chromosome-are associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of 3'-splice site during the early stages of spliceosome assembly; however, its precise role in RNA splicing has remained unclear. Here we characterize ZRSR2 as an essential component of the minor spliceosome (U12 dependent) assembl...
متن کاملClassification of Introns: U2-Type or U12-Type
splicing group II introns, which commonly have AC at The highly conserved dinucleotides GT and AG at intron their 39 boundary and 7 to 8 nucleotides separating the 59 and 39 boundaries, respectively, were recognized with 39 splice site from the branch site. This similarity might the sequencing of the first introns. These consensus indicate that the U12-type spliceosome may be more dinucleotides...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2007
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkm026