Amelogenin-Cytokeratin 14 Interaction in Ameloblasts during Enamel Formation
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چکیده
منابع مشابه
Amelogenin-cytokeratin 14 interaction in ameloblasts during enamel formation.
The enamel protein amelogenin binds to the GlcNAc-mimicking peptide (GMp) (Ravindranath, R. M. H., Tam, W., Nguyen, P., and Fincham, A. G. (2000) J. Biol. Chem. 275, 39654-39661). The GMp motif is found in the N-terminal region of CK14, a differentiation marker for ameloblasts. The binding affinity of CK14 and amelogenin was confirmed by dosimetric binding of CK14 to recombinant amelogenin (rM1...
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Ameloblasts from different regions of upper incisors of rats were examined with the electron microscope. During matrix formation, the cells resemble secretory cells. They are extremely long, tightly packed, and show considerable polarity. Nuclei are at the basal end of the cell. Mitochondria are proximal and the Golgi apparatus distal to the nucleus. Ergastoplasm is found in all levels but main...
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要 旨:幼 若エナ メル質 中に含 まれ ている有機質 のほ とん どを占めている蛋白質 は多成分系 であ る事 が知 ら れ てい る。それ らの うちの どの成分が生理的 に重要 なのかを明 らかにする 目的で,先 ずラ ッ ト幼若 エナ メル 蛋 白質についてゲル濾過 クロマ トグラフィー とSDS-ポ リアク リル ア ミ ドゲル電気泳動 を行 な って,石 灰 化 の進行 に伴 う蛋 白質 のパ ターンの変化 を調 べた。続 いて,ラ ッ トに3H-prolineを 静注 し,そ のエナメル質 へ の取込み の時間的 な変化 をゲル濾過 ク ロマ トグラフィー とポ リアク リル ア ミ ドゲル電気泳動 を行な って調 べ た。 その結果 は若 いstageのmain componentで ある分子量約20,000のproline,glutamic acid,histidi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m104656200