Aminoglycoside antibiotics and autism: a speculative hypothesis
نویسندگان
چکیده
منابع مشابه
Aminoglycoside antibiotics and autism: a speculative hypothesis
BACKGROUND Recently, it has been suspected that there is a relationship between therapy with some antibiotics and the onset of autism; but even more curious, some children benefited transiently from a subsequent treatment with a different antibiotic. Here, we speculate how aminoglycoside antibiotics might be associated with autism. PRESENTATION We hypothesize that aminoglycoside antibiotics c...
متن کاملAminoglycoside Antibiotics
Aminoglycosides are hydrophilic, polycationic, aminecontaining carbohydrates that are usually composed of three to five rings. Most aminoglycosides are either natural products or derivatives of soil actinomycetes. They are often secreted by these actinomycetes as mixtures of closely related compounds. The polycationic aminoglycoside chemical structure results in a binding both to the anionic ou...
متن کاملAminoglycoside antibiotics inhibit protein biosynthesis
RNA molecules have key roles in many essential biological processes, including protein synthesis, transcriptional regulation, mRNA splicing and retroviral replication. The structural diversity of RNA, together with the lack of known RNA repair mechanisms, make RNA a challenging and important target for therapeutic intervention [1]. Our understanding of the modes by which RNA is recognized by li...
متن کاملDNA-Aptamers Binding Aminoglycoside Antibiotics
Aptamers are short, single stranded DNA or RNA oligonucleotides that are able to bind specifically and with high affinity to their non-nucleic acid target molecules. This binding reaction enables their application as biorecognition elements in biosensors and assays. As antibiotic residues pose a problem contributing to the emergence of antibiotic-resistant pathogens and thereby reducing the eff...
متن کاملThe nature of concussion: a speculative hypothesis.
Concussion is one of the commonest forms of neurological injury seen throughout the world. Although common in sport, this condition has parallels in the types of injury suffered in motor vehicle crashes, falls, and other forms of brain trauma. Despite the fact that the eVects of brain injuries have been recognised for at least 3000 years and the clinical state of concussion initially described ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Psychiatry
سال: 2001
ISSN: 1471-244X
DOI: 10.1186/1471-244x-1-5