An Ancestral Haplotype Defines Susceptibility to Doxorubicin Nephropathy in the Laboratory Mouse
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چکیده
منابع مشابه
An ancestral haplotype defines susceptibility to doxorubicin nephropathy in the laboratory mouse.
Haplotype analysis was used to refine of the DOXNPH locus, which harbors the susceptibility gene for doxorubicin (DOX; Adriamycin) nephropathy, a Mendelian form of selective podocyte injury. Analysis of haplotype structure in three strains with contrasting susceptibility (148 single-nucleotide polymorphisms at 101-kb spacing) was complementary to analysis of recombinants in 176 F2 mice. For exa...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2006
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2005121373