An Effective Tri-Clustering Algorithm Combining Expression Data with Gene Regulation Information

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An Effective Tri-Clustering Algorithm Combining Expression Data with Gene Regulation Information

MOTIVATION Bi-clustering algorithms aim to identify sets of genes sharing similar expression patterns across a subset of conditions. However direct interpretation or prediction of gene regulatory mechanisms may be difficult as only gene expression data is used. Information about gene regulators may also be available, most commonly about which transcription factors may bind to the promoter regio...

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This paper presents two clustering methods: the first one uses a density-based approach (DGC) and the second one uses a frequent itemset mining approach (FINN). DGC uses regulation information as well as order preserving ranking for identifying relevant clusters in gene expression data. FINN exploits the frequent itemsets and uses a nearest neighbour approach for clustering gene sets. Both the ...

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ژورنال

عنوان ژورنال: Gene Regulation and Systems Biology

سال: 2009

ISSN: 1177-6250,1177-6250

DOI: 10.4137/grsb.s1150