An Epistemological Perspective on the Value of Gain-of-Function Experiments Involving Pathogens with Pandemic Potential
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چکیده
منابع مشابه
An Epistemological Perspective on the Value of Gain-of-Function Experiments Involving Pathogens with Pandemic Potential
In recent years, scientists have engaged in a vigorous debate regarding the value of so-called gain-of-function (GOF) experiments involving highly pathogenic avian influenza virus (HPAIV) and other pathogens with pandemic potential (PPP). Of particular concern have been experiments whereby something is done to PPP, such as HPAIV, and the pathogen acquires a new property, or GOF, that makes the ...
متن کاملmBio Addresses the Pause in Gain-of-Function (GOF) Experiments Involving Pathogens with Pandemic Potential (PPP)
Since the spring of 2014, there has been a vibrant debate in the scientific community about the benefits and risks of so-called gain-of-function (GOF) studies involving pathogens with pandemic potential and particularly highly pathogenic avian influenza virus (HPAIV) (1). In October 2014, the U.S. government announced a pause for research involving GOF experiments with three respiratory viruses...
متن کاملValuing Knowledge: a Reply to the Epistemological Perspective on the Value of Gain-of-Function Experiments
The central ethical claim of Casadevall et al. in “An Epistemological Perspective on the Value of Gain-of-Function Experiments Involving Pathogens with Pandemic Potential” (1) is that, when conducting risk-benefit analyses on studies that use gain-offunction (GOF) methods to create potential pandemic pathogens (PPP), we ought to explicitly account for the value of the “epistemic gains” of the e...
متن کاملVagueness and Costs of the Pause on Gain-of-Function (GOF) Experiments on Pathogens with Pandemic Potential, Including Influenza Virus
Since the spring of 2012, there has been a raging controversy in scientific circles on the wisdom of carrying out so-called “gainof-function” (GOF) experiments with pathogens of pandemic potential (PPP) such as influenza virus (1). Although the phrase “gain-of-function” has been much criticized because of its inexactness, the terminology has been adopted by many, including the media, to mean ex...
متن کاملReply to “Valuing Knowledge: a Reply to the Epistemological Perspective on the Value of Gain-of-Function Experiments”
We thank Dr. Evans for his letter (1). In reading his letter, it was difficult for us to sort out exactly what his criticism is of our editorial. However, we were able to discern three critical themes: (i) that we are guilty of “double counting” in the sense of counting both the benefits to human health from the knowledge gained via gain-of-function experiments on pathogens with pandemic potent...
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ژورنال
عنوان ژورنال: mBio
سال: 2014
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.01875-14