An Exceptionally Potent Inducer of Cytoprotective Enzymes
نویسندگان
چکیده
منابع مشابه
Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
The widespread belief that oxidative damage plays a major role in cancer, ageing, and in a number of chronic diseases has focused scienti®c and public attention on the possibility that antioxidants could prevent or at least retard these processes. Antioxidants are of two types: direct and indirect. Direct antioxidants [e.g. glutathione (GSH), tocopherols, ascorbic acid and carotenoids] are subs...
متن کاملCancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.
Induction of phase II enzymes is an important mechanism of chemoprevention. In our search for novel cancer chemopreventive agents, 4'-bromoflavone (4'BF) was found to significantly induce quinone reductase (QR) activity in cultured murine hepatoma 1c1c7 cells (concentration to double activity: 10 nM) and effectively induce the alpha- and mu-isoforms of glutathione S-transferase in cultured H4II...
متن کاملBroccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection against carcinogenesis, mutagenesis, and other forms of toxicity of electrophiles and reactive forms of oxygen. Since consumption of large quantities of fruit and vegetables is associated with a st...
متن کاملImmunoglobulin A1 Protease, an Exoenzyme of Pathogenic Neisseriae, Is a Potent Inducer of Proinflammatory Cytokines
A characteristic of human pathogenic Neisseriae is the production and secretion of an immunoglobulin (Ig)A1-specific serine protease (IgA1 protease) that cleaves preferentially human IgA1 and other target proteins. Here we show a novel function for native IgA1 protease, i.e., the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and ...
متن کاملCell-synthesized 3D Environment is a Potent Osteoblastic Inducer
Introduction For bone tissue engineering various scaffolds may be used, among which hydroxyapatite and tri-calcium phosphate (HA-TCP) ceramics are good candidates. Previous investigations have shown that human mesenchymal stem cells (hMSCs) seeded on small HA-TCP particles could form three dimensional (3D) constructs beneficial for osteoblastic differentiation in vitro [1]. However, within thes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.163485