An in vitro Skin Penetration Model for Compromised Skin: Estimating Penetration of Polyethylene Glycol [14C]-PEG-7 Phosphate
نویسندگان
چکیده
منابع مشابه
Development of an in vitro model for studying the penetration of chemicals through compromised skin.
The conventional safety approach that includes dermal absorption of pharmaceutical or consumer products uses models that are based on intact skin. However, when products are intended for application to skin with a less effective barrier, such as in new-born infants, or in cases where the skin is mildly damaged or diseased, there are instances where absorption through compromised skin is also im...
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Dermatological and cosmetic preparations frequently contain active principles which can only act when they penetrate at least the outermost layer of the skin. However, the efficacy of topically applied actives is often suboptimal because the transport into the skin is slow due to the resistance of the outermost layer of the skin, the stratum corneum. Most small water-soluble nonelectrolytes the...
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With the help of tissue engineering new products are realized. The purpose of the development is design 3D models with organ-specific characteristics to use them as test systems. With these models it is possible to test effectiveness as well as metabolisation of potential substances as e.g. for nanomaterials. This model can also represent an alternative to animal testing. Thus a possibility of ...
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ژورنال
عنوان ژورنال: Skin Pharmacology and Physiology
سال: 2015
ISSN: 1660-5535,1660-5527
DOI: 10.1159/000362284