An integrated semiconductor device enabling non-optical genome sequencing

An optical "Janus" device for integrated photonics.

Adv. Mater. 2010, 22, 2561–2564 2010 WILEY-VCH Verlag G T IO N In Roman mythology, the god Janus was depicted with two faces, looking in opposite directions. This led to the phrase ‘‘Janus faced’’ which is mostly used for a ‘‘two-faced’’ or deceitful character of a person. Within integrated photonics a concept like Janus can provide a new class of multi-functional optical meta-elements which co...

Supporting Information An Optical “Janus” Device for Integrated Photonics

Device design using quasi-conformal mapping Figure 1 in the main text specifies how the boundaries between the virtual and the physical spaces of our device are transformed into each other. In principle, any coordinate map satisfying such a transformation can be used to construct the actual permittivity profile. However, this would lead in general to a very anisotropic permittivity for the stru...

Whole Genome Sequencing: An Efficient Approach in Food Safety Management System

Semiconductor-based sequencing of genome-wide DNA methylation states

Methylated DNA immunoprecipitation sequencing (MeDIP-Seq) is a widely used approach to study DNA methylation genome-wide. Here, we developed a MeDIP-Seq protocol compatible with the Ion Torrent semiconductor-based sequencing platform that is low cost, rapid, and scalable. We applied this protocol to demonstrate MeDIP-Seq on the Ion Torrent platform provides adequate coverage of CpG cytosines, t...

Designing an Integrated All-Optical Analog to Digital Converter

We present the procedure for designing a high speed and low power all-optical analog to digital converter (AO-ADC), by integrating InGaAsP semiconductor optical amplifier (SOA) with InP based photonic crystal (PhC) drop filters. The self-phase modulation in the SOA can shift the frequency of the Gaussian input pulse. The two output PhC based drop filters are designed to appropriately code the f...