Analysis of 14-3-3 isoforms expressed in photoreceptors
نویسندگان
چکیده
منابع مشابه
Characterization of 14-3-3 isoforms expressed in the Echinococcus granulosus pathogenic larval stage.
The 14-3-3 protein family of eukaryotic regulators was studied in Echinococcus granulosus, the causative agent of cystic hydatid disease. These proteins mediate important cellular processes in eukaryotes and are expected to play important roles in parasite biology. Six isoforms of E. granulosus 14-3-3 genes and proteins (Eg14-3-3.1-6) were analyzed, and their phylogenetic relationships were est...
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NRL, a bZIP transcription factor of the Maf subfamily, interacts with the homeodomain protein CRX and synergistically regulates rhodopsin expression. Here we report that six isoforms of NRL (29-35 kDa) are generated by phosphorylation and expressed specifically in the mammalian retina. The anti-NRL antibody also cross-reacts with a cytosolic 45-kDa protein, which is detected in neuronal tissues...
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p53 maintains genome integrity by initiating the transcription of genes involved in cell-cycle arrest, senescence, apoptosis and DNA repair. The activity of p53 is regulated by both post-translational modifications and protein-protein interactions. p53 that has been phosphorylated at S366, S378 and T387 binds 14-3-3 proteins in vitro. Here, we show that these sites are potential 14-3-3 binding ...
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Cholangiocarcinoma (CCA) is an adenocarcinoma arising from the epithelial tissue of the intra-hepatic (10%), hepatic hilar (25%) or extrahepatic (65%) bile ducts (Lim, 2003). It is accounting for approximately 3% of all gastrointestinal malignancies (Wijaya and Abdullah, 2011). Recent data show that the incidence of cholangiocarcinoma have been increasing in several areas worldwide (Shu et al.,...
متن کاملTransgenic 14-3-3 isoforms in plants: the metabolite profiling of repressed 14-3-3 protein synthesis in transgenic potato plants.
14-3-3 proteins are abundant eukaryotic proteins that interact with many other proteins, thereby modulating their function and thus cell metabolism. The data from mRNA analysis confirm the developmental regulation of 14-3-3 isoform expression in potato plants. In order to test whether or not 14-3-3 protein expression affects plant phenotype and metabolism, transgenic potato plants either overex...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2018
ISSN: 0014-4835
DOI: 10.1016/j.exer.2018.02.022