Analysis of change in mitochondrial membrane potential on Intracellular signal transduction.

The effect of aminoguanidine on sperm motility and mitochondrial membrane potential in varicocelized rats

Objective(s): Increased levels of nitric oxide (NO) in the testicular veins of people suffering from varicocele have already been reported. However, the role of NO-synthase (NOS) isozymes and their inhibitors have not been extensively studied. We aimed to evaluate the inhibitory effects of aminoguanidine (AG), on sperm motility, vitality, and mitochondrial membrane potential (MMP) in varicoceli...

Methods for the Analysis of Intracellular Signal Transduction Systems

This chapter introduces some practical methods for the analysis of intracellular signal transduction systems. If a biological system is described by a linear ordinary differential equation, various analytical tools are available to elucidate a control mechanism for the system in question. However, few systematic methods are available for nonlinear systems in which it is more capable of wide app...

Systems biological analyses of intracellular signal transduction

On the calculation of signal transduction ability of signaling transduction pathways in intracellular communication: systematic approach

MOTIVATION The major function of signal transduction pathways in cells is to sense signals from the environment and process the information through signaling molecules in order to regulate the activity of transcription factors. On the molecular level, the information transmitted by a small number of signal molecules is amplified in the internal signaling pathway through enzyme catalysis, molecu...

Neurotrophic Factors and Intracellular Signal Transduction Pathways

A clear limitation of treating diseases of the central nervous system arises from the loss of regenerative potential of the brain at a very early age. Improper development of neural circuits or injury of neurons appears to be permanently fixed in the adult, with seemingly little hope of restorative therapy. This is most clearly true of the spectrum of neurologic diseases, such as neurodegenerat...